Investigating how a protein modification affects heart health
Wrestling stress: role of ufm1 modification in pathological cardiac remodeling
This study is looking at how a special change to a protein, called ufmylation, affects heart health and could help us understand and treat heart problems like cardiomyopathy and heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-10770483 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein modification, known as ufmylation, in heart function and disease. By studying how ufmylation affects cardiac cells, the researchers aim to uncover its impact on heart conditions such as cardiomyopathy and heart failure. The approach involves examining the mechanisms by which ufmylation regulates cellular processes and contributes to heart health, particularly under stress conditions. Patients may benefit from insights gained about how to prevent or treat heart diseases linked to this protein modification.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of heart disease, particularly those with cardiomyopathy or heart failure.
Not a fit: Patients with non-cardiac related conditions or those without any heart disease may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating heart diseases, particularly those related to aging and stress.
How similar studies have performed: Previous research has shown promising results in understanding protein modifications in heart disease, suggesting that this approach may yield valuable insights.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Li, Jie — Augusta University
- Study coordinator: Li, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.