Investigating how a protein modification affects heart failure
O-GlcNAcylation and YAP: Defining a novel pathway in heart failure
This study is looking at how a specific protein change in the heart might affect heart failure, using specially modified mice to see if adjusting this change could help prevent heart problems, which could lead to new ways to treat heart conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11324085 on NIH RePORTER |
What this research studies
This research explores the role of O-GlcNAcylation, a modification of proteins, in heart failure. It aims to understand how changes in this modification can influence heart health and disease, particularly through the study of genetically modified mice. By examining the effects of increased and decreased O-GlcNAcylation in the heart, the research seeks to uncover potential therapeutic targets for preventing heart failure. The findings could lead to new strategies for managing heart conditions by targeting specific proteins involved in heart stress responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure or those at high risk for developing heart failure.
Not a fit: Patients with heart conditions unrelated to O-GlcNAcylation or those who do not have heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or mitigate heart failure in patients.
How similar studies have performed: Previous research has shown promising results in understanding protein modifications in heart disease, suggesting potential for success in this novel approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Umapathi, Mahaa — Johns Hopkins University
- Study coordinator: Umapathi, Mahaa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.