Investigating how a protein modification affects heart failure
O-GlcNAcylation and YAP: Defining a novel pathway in heart failure
['FUNDING_CAREER'] · JOHNS HOPKINS UNIVERSITY · NIH-10898726
This study is looking at how a specific protein change in the body might affect heart failure, using special mice to learn more about how it works, with hopes that the results could help create new treatments to keep hearts healthier.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10898726 on ClinicalTrials.gov |
What this research studies
This research explores the role of O-GlcNAcylation, a modification of proteins, in heart failure. It examines how changes in this modification can either contribute to or protect against heart disease. Using genetically modified mice, the study aims to understand the mechanisms behind heart stress and failure, focusing on the enzymes that regulate O-GlcNAcylation. The findings could lead to new therapies targeting this pathway to improve heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure or those at high risk for developing heart failure.
Not a fit: Patients with heart conditions unrelated to O-GlcNAcylation or those who do not have heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or mitigate heart failure.
How similar studies have performed: Previous research has shown promising results in understanding the role of protein modifications in heart disease, suggesting potential for success in this novel approach.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UMAPATHI, MAHAA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: UMAPATHI, MAHAA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.