Investigating how a protein linked to neurodegeneration affects cell health
Redox regulation of protein functions linked to neurodegeneration
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10904159
This study is looking at a protein called ataxin-2 to see how it affects brain cell health in conditions like ALS, and it hopes to find new ways to help patients by understanding how changes in this protein can lead to cell damage.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10904159 on ClinicalTrials.gov |
What this research studies
This research explores the role of a protein called ataxin-2 in neurodegeneration, particularly in conditions like Amyotrophic Lateral Sclerosis (ALS). It aims to understand how ataxin-2 functions as a redox sensor, which helps regulate cellular metabolism and maintain mitochondrial health. By studying both yeast and mammalian cells, the research will examine how mutations in this protein can impact its normal functions and contribute to cell death. Patients may benefit from insights into the mechanisms of neurodegeneration and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases, particularly those with ALS.
Not a fit: Patients with neurodegenerative conditions unrelated to ataxin-2 or those without a diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodegenerative diseases like ALS.
How similar studies have performed: Previous research has shown promising results in understanding protein functions related to neurodegeneration, suggesting potential for breakthroughs in this area.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TU, BENJAMIN P — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: TU, BENJAMIN P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease, Gehrig's Disease, Lou Gehrig Disease