Investigating how a protein linked to neurodegeneration affects cell health
Redox regulation of protein functions linked to neurodegeneration
This study is looking at a protein called ataxin-2 to see how it affects cell health in conditions like ALS, hoping to learn more about how it helps keep our cells working well and what happens when it’s not functioning properly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10679058 on NIH RePORTER |
What this research studies
This research explores the role of a protein called ataxin-2 in neurodegeneration, particularly in conditions like Amyotrophic Lateral Sclerosis (ALS). It aims to understand how ataxin-2 functions as a redox sensor, which helps regulate cellular metabolism and maintain mitochondrial health. By studying both yeast and mammalian cells, the research will examine how mutations in this protein impact its function and the overall health of cells. This could provide insights into the underlying mechanisms of neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases, particularly those with ALS.
Not a fit: Patients with neurodegenerative diseases not related to ALS or those without any neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodegenerative diseases like ALS.
How similar studies have performed: Previous research has shown promising results in understanding the role of proteins in neurodegeneration, making this approach both relevant and potentially impactful.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Tu, Benjamin P — Ut Southwestern Medical Center
- Study coordinator: Tu, Benjamin P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.