Investigating how a protein interaction affects kidney cyst growth in a genetic kidney disease.
Pannexin-1/P2X7 interaction promotes excessive ATP release in kidney cysts and ADPKD progression via reduced NaCl reabsorption
['FUNDING_R01'] · WAYNE STATE UNIVERSITY · NIH-10817820
This study is looking at how certain molecules and proteins affect cyst growth in autosomal dominant polycystic kidney disease (ADPKD), with the hope of finding new ways to slow down or prevent kidney problems for people living with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAYNE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (DETROIT, UNITED STATES) |
| Trial ID | NIH-10817820 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the mechanisms behind cyst growth in autosomal dominant polycystic kidney disease (ADPKD), a common inherited kidney disorder. It examines the role of ATP, a molecule that regulates kidney function, and how its release is influenced by specific proteins called pannexins and P2X7 receptors. By studying these interactions, the research aims to identify potential therapeutic targets that could slow down or prevent the progression of kidney cysts. Patients may benefit from insights that could lead to new treatments for managing ADPKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease (ADPKD).
Not a fit: Patients with other forms of kidney disease or those without a genetic predisposition to ADPKD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow the progression of kidney cysts in patients with ADPKD.
How similar studies have performed: Other research has shown promising results in targeting similar pathways in kidney diseases, suggesting potential for success in this approach.
Where this research is happening
DETROIT, UNITED STATES
- WAYNE STATE UNIVERSITY — DETROIT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAVLOV, TENGIS S — WAYNE STATE UNIVERSITY
- Study coordinator: PAVLOV, TENGIS S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.