Investigating how a protein influences certain immune cells that can cause inflammation
How beta-catenin expands Foxp3+RORgammat+ Pro-inflammatoryT-regulatory cells - Renewal
This study is looking at a special type of immune cell that can cause more inflammation in conditions like inflammatory bowel diseases, colon cancer, and multiple sclerosis, to see how a protein called beta-catenin affects their behavior, which could help us find new ways to treat these conditions and improve how the immune system works for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-10895577 on NIH RePORTER |
What this research studies
This research focuses on understanding a specific subset of regulatory T cells (Tregs) that express high levels of beta-catenin, which are linked to increased inflammation in conditions like inflammatory bowel diseases, colon cancer, and multiple sclerosis. The study aims to explore how beta-catenin affects the behavior of these Tregs and their ability to suppress inflammation. By examining the genetic and functional characteristics of these cells, the research seeks to uncover new insights into their role in autoimmune diseases and potential therapeutic targets. Patients may benefit from a better understanding of how their immune response is regulated and how it can be manipulated for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases such as inflammatory bowel disease, multiple sclerosis, or colon cancer.
Not a fit: Patients with non-autoimmune conditions or those not affected by inflammation-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage autoimmune diseases and inflammatory conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of Tregs in inflammation, suggesting that this approach could yield significant insights.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Gounari, Fotini — Mayo Clinic Arizona
- Study coordinator: Gounari, Fotini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.