Investigating how a protein in breast milk affects immune tolerance in infants
Milk Butryophilin and Immune Tolerence
['FUNDING_R21'] · YALE UNIVERSITY · NIH-11083041
This study is looking at how a protein in breast milk called BTN1A1 helps babies' immune systems work better, which might protect them from allergies and autoimmune diseases as they grow up.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11083041 on ClinicalTrials.gov |
What this research studies
This research explores the role of butyrophilin (BTN1A1), a protein found in breast milk, in shaping the immune system of infants. It aims to understand how BTN1A1 influences T cell activation and tolerance, potentially protecting against allergic and autoimmune diseases. The study will involve testing the effects of BTN1A1 on T cell responses in neonatal models, with a focus on how these effects may persist beyond weaning. By examining these mechanisms, the research seeks to uncover how breastfeeding can provide lasting immune benefits to children.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants under 11 years old, particularly those at risk for allergic or autoimmune conditions.
Not a fit: Patients who are older than 11 years or those who are not breastfed may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing allergic diseases in children through enhanced understanding of breast milk's immune properties.
How similar studies have performed: Previous studies have shown that components in breast milk can influence immune development, suggesting that this research builds on established findings in the field.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WYSOLMERSKI, JOHN J — YALE UNIVERSITY
- Study coordinator: WYSOLMERSKI, JOHN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway Disease, Allergic Disease