Investigating how a protein helps kidney cells respond to mechanical stress
Official title: The Role of LIM-nebulette in podocyte mechanoresponse
Funded at Icahn School of Medicine at Mount Sinai · NIH-10998990 · Data updated 2026-11-12
This study is looking at special kidney cells called podocytes to see how they change when they face pressure, like high blood pressure, and how a protein called LIM-nebulette helps keep them healthy, which could help us find new ways to treat kidney diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,814 |
| NIH project number | 1F31DK141253-01 |
| Project ID | NIH-10998990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old who have conditions affecting kidney function.
✕Less likely to help
Patients with stable kidney function and no underlying kidney disease may not benefit from this research.
What this research studies
This research focuses on podocytes, specialized kidney cells that play a crucial role in filtering blood. It examines how these cells restructure their internal framework in response to mechanical stress, such as high blood pressure. The study utilizes a unique instrument that mimics the forces podocytes experience in the body, allowing researchers to analyze how a specific protein, LIM-nebulette, helps maintain the integrity of these cells. By combining advanced imaging techniques and biochemical analysis, the research aims to uncover the protective mechanisms of podocytes, which could lead to new treatments for kidney diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving kidney function in patients with kidney diseases.
How similar studies have gone: Previous research has shown promising results in understanding cellular responses to mechanical stress, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Wright, Jacob Matthew — Icahn School of Medicine at Mount Sinai
- Study coordinator: Wright, Jacob Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.