Investigating how a protein helps cells sense low oxygen levels
SREBP1 as a Novel Mammalian Oxygen Sensor
This study is looking at how certain cells in the body respond to low oxygen levels, which is a common issue for people with heart and lung diseases, and it will explore a protein that might help these cells adapt, with the hope of finding new ways to help patients feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11061847 on NIH RePORTER |
What this research studies
This research focuses on understanding how cells and tissues in mammals detect and adapt to low oxygen levels, a condition common in patients with cardiopulmonary diseases like chronic obstructive pulmonary disease and heart failure. The study will explore the role of a specific protein, SREBP1, which may act as an oxygen sensor, helping to regulate lipid metabolism in response to oxygen availability. By uncovering these mechanisms, the research aims to identify new therapeutic strategies to improve patient outcomes in those suffering from chronic hypoxia. The project will involve both laboratory experiments and analysis of biological data to validate the findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic cardiopulmonary diseases, particularly those experiencing chronic hypoxia.
Not a fit: Patients with conditions unrelated to oxygen sensing or those not experiencing chronic hypoxia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the health and quality of life for patients with chronic hypoxia-related conditions.
How similar studies have performed: Previous research has shown promising results in understanding oxygen sensing mechanisms in other organisms, suggesting potential for success in this novel approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Baik, Alan Hyun — University of California, San Francisco
- Study coordinator: Baik, Alan Hyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.