Investigating how a protein helps bacteria recover from antibiotic stress
The role of HrpA in ribosome-associated quality control in E. coli
This study is looking at how a protein called HrpA helps E. coli bacteria deal with the stress of antibiotics, especially when their protein-making machinery gets stuck, and it hopes to find new ways to fight antibiotic-resistant infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10902014 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein, HrpA, in helping E. coli bacteria manage and recover from the stress caused by antibiotics. The study examines how ribosomes, which are essential for protein synthesis, can become stalled during this process and how HrpA may assist in resolving these stalls. By exploring the mechanisms behind ribosome rescue, the research aims to uncover new insights into bacterial survival and antibiotic resistance. This could lead to a better understanding of how to combat antibiotic-resistant infections.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by bacteria or are not antibiotic-resistant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for overcoming antibiotic resistance in bacterial infections.
How similar studies have performed: Other research has shown success in understanding ribosome rescue mechanisms in various organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Campbell, Annabelle — Johns Hopkins University
- Study coordinator: Campbell, Annabelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.