Investigating how a protein from Streptococcus pyogenes interacts with heme and its cofactors
Structure-Function Relationship study of HupZ
This study is looking at a protein from a germ that can cause infections, to learn how it uses a special molecule called heme, which might help us find new ways to treat these infections and keep you healthier.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10863866 on NIH RePORTER |
What this research studies
This research focuses on a protein called HupZ from the bacterium Streptococcus pyogenes, which is known to cause various diseases. The study aims to understand how HupZ interacts with heme and its cofactors through biochemical and structural methods. By examining the protein's structure and function, researchers hope to uncover its role in the heme utilization pathway, which could lead to insights into bacterial metabolism and potential therapeutic targets. Patients may benefit from this research as it could inform new strategies for treating infections caused by this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by infections caused by Streptococcus pyogenes or those at risk of such infections.
Not a fit: Patients with infections caused by other pathogens unrelated to Streptococcus pyogenes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating infections caused by Streptococcus pyogenes.
How similar studies have performed: Other research has shown success in understanding bacterial proteins and their roles in disease, suggesting that this approach could yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas San Antonio — San Antonio, United States (Active)
Researchers
- Principal investigator: Traore, Ephrahime — University of Texas San Antonio
- Study coordinator: Traore, Ephrahime
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.