Investigating how a protein complex affects heart gene activity and function
Role of Negative Elongation Factor Complex in RNA polymerase II pausing and gene transcription in Heart
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11004685
This study is looking at how a specific protein complex in the heart helps control the way genes are turned on and off, especially when the heart is under stress from conditions like thickening of the heart muscle or heart failure, with the goal of finding new ways to improve treatments for people with heart problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11004685 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the Negative Elongation Factor Complex in regulating gene transcription in the heart, particularly during conditions like cardiac hypertrophy and heart failure. The study aims to uncover the mechanisms that control RNA polymerase II pausing, which is crucial for proper gene expression in cardiac muscle cells. By analyzing changes in the expression of specific proteins and their impact on heart function, the research seeks to identify potential targets for improving treatment outcomes for patients with heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cardiac hypertrophy or chronic heart failure.
Not a fit: Patients with non-cardiac related conditions or those without any form of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve heart function and outcomes for patients with heart failure.
How similar studies have performed: Other research has shown promising results in understanding gene regulation in heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAYED, DANISH — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: SAYED, DANISH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.