Investigating how a protein complex affects cell signaling and adhesion
Official title: Structure and Function of an ADAM10-Tspan5 Complex
Funded at Harvard Medical School · NIH-10995724 · Data updated 2026-11-12
This study is looking at how a protein called ADAM10 works with other proteins to help cells communicate and stick together, which could help us find better treatments for diseases like cancer and neurodegenerative disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32GM155967-01 |
| Project ID | NIH-10995724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals affected by neurodegenerative diseases or cancers linked to ADAM10 dysfunction.
✕Less likely to help
Patients with conditions unrelated to cell signaling or adhesion mechanisms may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of the ADAM10 protein and its interaction with tetraspanins in regulating cell signaling and adhesion. By studying how these proteins interact and influence each other, the research aims to uncover mechanisms that could lead to better treatments for diseases where these processes are disrupted, such as neurodegenerative diseases and cancers. The approach involves biochemical assays and structural analysis to elucidate the function of this protein complex. Patients may benefit from insights gained that could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases and certain cancers by targeting the mechanisms of cell signaling and adhesion.
How similar studies have gone: Previous research has shown success in targeting similar protein interactions for therapeutic benefits, indicating potential for this approach.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Price, Owen M — Harvard Medical School
- Study coordinator: Price, Owen M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.