Investigating how a protein called SHARPIN affects platelet and blood vessel functions.
Role of SHARPIN in the Adhesive and Inflammatory Functions of Platelets and Endothelial Cells
['FUNDING_P01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10902044
This study is looking at a protein called SHARPIN to see how it helps platelets and blood vessel cells work together during blood clotting and inflammation, which could lead to better ways to manage conditions related to these processes for patients.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10902044 on ClinicalTrials.gov |
What this research studies
This research explores the role of SHARPIN, a protein found in platelets and endothelial cells, in regulating how these cells interact during blood clotting and inflammation. By examining how SHARPIN influences the binding of fibrinogen to platelets, the study aims to uncover new mechanisms that could affect blood coagulation and inflammatory responses. The research involves using human platelets and stem cell-derived megakaryocytes to analyze the effects of SHARPIN on platelet function and signaling pathways. Patients may benefit from insights gained into how to better manage conditions related to blood clotting and inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to abnormal blood clotting or inflammation.
Not a fit: Patients who do not have issues related to blood coagulation or inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with blood clotting disorders or inflammatory diseases.
How similar studies have performed: Previous research has shown promising results in understanding the roles of similar proteins in platelet function, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHATTIL, SANFORD J — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: SHATTIL, SANFORD J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.