Investigating how a protein called Prohibitin protects the brain from injury.
Role of Prohibitin Nitrosylation in its Neuroprotective Functions
This study is looking at a protein called Prohibitin that helps protect brain cells during strokes, and it aims to find out how a molecule called nitric oxide influences this protection, which could lead to new treatments for brain injuries that might help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11086167 on NIH RePORTER |
What this research studies
This research focuses on the role of a mitochondrial protein known as Prohibitin (PHB) in protecting brain cells from damage caused by ischemic events, such as strokes. The study aims to understand how PHB is regulated by nitric oxide and how this regulation affects its neuroprotective functions. By exploring the mechanisms of PHB's action, the research seeks to uncover new insights into how to enhance brain protection during injury. Patients may benefit from findings that could lead to new treatments for brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced or are at risk for ischemic brain injuries.
Not a fit: Patients with non-ischemic brain injuries or those with advanced neurological diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for protecting the brain from injuries like strokes.
How similar studies have performed: Previous research has shown that targeting mitochondrial proteins can be effective in neuroprotection, suggesting a promising avenue for this investigation.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Zhou, Ping — Weill Medical Coll of Cornell Univ
- Study coordinator: Zhou, Ping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.