Investigating how a protein called Meningioma-1 contributes to aggressive leukemia.
A stalled chromatin regulatory network that mediates the oncogenic activity of Meningioma-1
This study is looking at a protein called MN1 to see how it affects blood cells in people with acute myeloid leukemia (AML), with the hope of finding new treatment options for those who aren't responding well to current therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11061004 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the protein Meningioma-1 (MN1) in acute myeloid leukemia (AML), a type of cancer that affects the blood and bone marrow. Researchers will explore how MN1 interacts with other proteins to influence the behavior of blood cells, particularly in the context of leukemia. By studying these molecular mechanisms, the project aims to identify potential new therapies for patients who do not respond well to existing treatments for AML.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia, particularly those with high levels of Meningioma-1.
Not a fit: Patients with other types of leukemia or those who do not have elevated Meningioma-1 levels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve outcomes for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promising results in targeting similar molecular pathways in leukemia, suggesting that this approach may be effective.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Bernt, Kathrin M — Children's Hosp of Philadelphia
- Study coordinator: Bernt, Kathrin M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.