Investigating how a protein called Meningioma-1 contributes to aggressive leukemia.
Official title: A stalled chromatin regulatory network that mediates the oncogenic activity of Meningioma-1
Funded at Children's Hosp of Philadelphia · NIH-11061004 · Data updated 2026-11-12
This study is looking at a protein called MN1 to see how it affects blood cells in people with acute myeloid leukemia (AML), with the hope of finding new treatment options for those who aren't responding well to current therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $438,480 |
| NIH project number | 5R01CA262260-04 |
| Project ID | NIH-11061004 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia, particularly those with high levels of Meningioma-1.
✕Less likely to help
Patients with other types of leukemia or those who do not have elevated Meningioma-1 levels may not benefit from this research.
What this research studies
This research focuses on understanding the role of the protein Meningioma-1 (MN1) in acute myeloid leukemia (AML), a type of cancer that affects the blood and bone marrow. Researchers will explore how MN1 interacts with other proteins to influence the behavior of blood cells, particularly in the context of leukemia. By studying these molecular mechanisms, the project aims to identify potential new therapies for patients who do not respond well to existing treatments for AML.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve outcomes for patients with acute myeloid leukemia.
How similar studies have gone: Previous research has shown promising results in targeting similar molecular pathways in leukemia, suggesting that this approach may be effective.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Bernt, Kathrin M — Children's Hosp of Philadelphia
- Study coordinator: Bernt, Kathrin M
Related research
Other NIH-funded projects on the same topics.
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Meningioma biology and new therapies guided by molecular profiling
A large, multi-institution study is exploring how meningiomas grow and respond to treatment, using advanced molecular profiling to find safer, more effective ways to manage them.
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Biomarker-based guidance to predict meningioma outcomes and radiotherapy response
A gene-based test is being developed to help predict how meningioma tumors will behave and how patients may respond to radiotherapy.
-
Meningioma radiotherapy response: understanding gene clues and how to tailor treatment
A short research project will study why some meningioma tumors respond differently to radiotherapy by looking at gene activity and how it affects treatment outcomes.
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Genomic and biochemical clues behind meningioma race differences and outcomes
This grant aims to uncover biological and environmental factors that cause differences in meningioma occurrence and treatment results across racial groups, with the goal of improving care for patients affected by this brain tumor.
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How the MN1 protein drives aggressive acute myeloid leukemia
This project looks at how the MN1 protein and its partner BAF complex keep leukemia genes active in people with acute myeloid leukemia to reveal new treatment targets.
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How meningiomas change over time and new treatment targets
This project looks for molecular signs that predict which meningiomas will come back and finds drug targets to help people with aggressive or recurrent tumors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.