Investigating how a protein called ISG15 affects aging and cancer-related cell behavior.
The role of ISG15 and ISGylation in the senescence-associated secretory phenotype
This study is looking at a protein called ISG15 to see how it affects aging and diseases like cancer and inflammation, hoping to find ways to help people understand and possibly treat these age-related issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10788670 on NIH RePORTER |
What this research studies
This research explores the role of ISG15, a protein that modifies other proteins, in cellular aging and its impact on age-related diseases like cancer and inflammation. The study focuses on how ISG15 is involved in the senescence-associated secretory phenotype (SASP), which can negatively affect surrounding cells. By examining how ISG15 levels change in response to DNA damage and stress, the research aims to uncover its contributions to cellular senescence and the potential for therapeutic interventions. Patients may benefit from insights into how aging and cancer progression are linked to cellular changes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing age-related diseases, particularly those with conditions like cancer or chronic inflammation.
Not a fit: Patients with acute, non-age-related conditions or those not affected by cellular senescence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating age-related diseases and cancers by targeting the mechanisms of cellular senescence.
How similar studies have performed: Previous research has shown promising results in understanding the role of ISG15 in cellular processes, indicating potential for success in this area.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Klingelhutz, Aloysius John — University of Iowa
- Study coordinator: Klingelhutz, Aloysius John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.