Investigating how a protein called DAXX affects cancer development and protein folding.
Role of Daxx in protein folding and tumorigenesis
This study is looking at a protein called DAXX to see how it might help prevent pancreatic neuroendocrine tumors from growing, and the findings could lead to new treatments for patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10689110 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the DAXX protein in the development of tumors, particularly pancreatic neuroendocrine tumors (PanNETs). The study aims to explore how DAXX functions as a catalyst for protein folding and how its dysregulation may contribute to cancer progression. By examining the molecular mechanisms and interactions of DAXX, researchers hope to uncover new insights into its tumor-suppressive properties. Patients may benefit from this research as it could lead to novel therapeutic strategies targeting DAXX-related pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic neuroendocrine tumors or those with mutations in the DAXX gene.
Not a fit: Patients with cancers unrelated to DAXX or those without pancreatic neuroendocrine tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for pancreatic neuroendocrine tumors and potentially other cancers.
How similar studies have performed: Other research has shown promising results in understanding the role of protein folding in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Yang, Xiaolu — University of Pennsylvania
- Study coordinator: Yang, Xiaolu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.