Investigating how a protein called Connexin 43 controls cancer cell behavior
Connexin 43 Phosphorylation as a Regulatory Mechanism of Src Activity
['FUNDING_R15'] · MORAVIAN UNIVERSITY · NIH-10580186
This study is looking at a protein called Connexin 43 that helps cells talk to each other and can slow down cancer growth, and it's for anyone interested in new ways to treat cancer by targeting a specific enzyme that often goes haywire in cancer cells.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MORAVIAN UNIVERSITY (nih funded) |
| Locations | 1 site (BETHLEHEM, UNITED STATES) |
| Trial ID | NIH-10580186 on ClinicalTrials.gov |
What this research studies
This research focuses on Connexin 43 (Cx43), a protein that plays a crucial role in cell communication and is involved in regulating cancer cell growth. The study aims to understand how Cx43 interacts with a specific enzyme, Src, which is often overactive in cancer cells. By exploring the phosphorylation process of Cx43, the researchers hope to uncover how this protein can inhibit Src activity and potentially slow down cancer cell proliferation. The ultimate goal is to develop Cx43-based peptides that could serve as new treatments for cancer by targeting Src.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals diagnosed with cancers characterized by overactive Src activity.
Not a fit: Patients with cancers not associated with Src activity or those without a diagnosis of malignancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new cancer therapies that effectively inhibit tumor growth by targeting specific cellular mechanisms.
How similar studies have performed: While the specific approach of targeting Cx43 in relation to Src is novel, similar strategies targeting cell signaling pathways have shown promise in other cancer research.
Where this research is happening
BETHLEHEM, UNITED STATES
- MORAVIAN UNIVERSITY — BETHLEHEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THEVENIN, ANASTASIA — MORAVIAN UNIVERSITY
- Study coordinator: THEVENIN, ANASTASIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers