Investigating how a protein called alpha-catenin helps maintain cell connections in tissues.
Official title: Alpha-catenin phosphorylation is mechanosensitive and required for epithelial barrier structure-function
Funded at Northwestern University at Chicago · NIH-10995086 · Data updated 2026-11-12
This study is looking at how a protein called alpha-catenin helps cells stick together and stay strong in our tissues, especially when they experience different physical forces, which could help us understand how to keep our tissues healthy during development.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $41,384 |
| NIH project number | 1F30EY036267-01A1 |
| Project ID | NIH-10995086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting epithelial tissues, such as inflammatory bowel disease or skin disorders.
✕Less likely to help
Patients with conditions unrelated to epithelial barrier function or those not experiencing tissue adhesion issues may not benefit from this research.
What this research studies
This research focuses on understanding how the protein alpha-catenin, which plays a crucial role in cell adhesion, is regulated by mechanical signals and phosphorylation. By studying this protein's behavior in epithelial cells, the research aims to uncover how it contributes to the integrity of tissue barriers during development. The team will utilize various cell models to explore the dynamic interactions between alpha-catenin and the actin cytoskeleton, particularly how these interactions are affected by mechanical forces. This could provide insights into the fundamental processes that maintain healthy tissue structure and function.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing tissue repair and preventing diseases related to epithelial barrier dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding cell adhesion mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Quinn, Jeanne Marie — Northwestern University at Chicago
- Study coordinator: Quinn, Jeanne Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.