Investigating how a protein called alpha-catenin helps maintain cell connections in tissues.
Alpha-catenin phosphorylation is mechanosensitive and required for epithelial barrier structure-function
['FUNDING_FELLOWSHIP'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10995086
This study is looking at how a protein called alpha-catenin helps cells stick together and stay strong in our tissues, especially when they experience different physical forces, which could help us understand how to keep our tissues healthy during development.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10995086 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the protein alpha-catenin, which plays a crucial role in cell adhesion, is regulated by mechanical signals and phosphorylation. By studying this protein's behavior in epithelial cells, the research aims to uncover how it contributes to the integrity of tissue barriers during development. The team will utilize various cell models to explore the dynamic interactions between alpha-catenin and the actin cytoskeleton, particularly how these interactions are affected by mechanical forces. This could provide insights into the fundamental processes that maintain healthy tissue structure and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting epithelial tissues, such as inflammatory bowel disease or skin disorders.
Not a fit: Patients with conditions unrelated to epithelial barrier function or those not experiencing tissue adhesion issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing tissue repair and preventing diseases related to epithelial barrier dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding cell adhesion mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QUINN, JEANNE MARIE — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: QUINN, JEANNE MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.