Investigating how a protein affects the survival of immune cells in the body
Role of apoE in HDL-mediated enhanced survival of human regulatory T-cells
This study is looking at how a protein called apoE helps certain immune cells, which are important for keeping inflammation in check, live longer and work better, with the hope of finding new ways to treat autoimmune and inflammatory diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11004681 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein called apoE in enhancing the survival of regulatory T-cells, which are crucial for controlling inflammation and maintaining immune balance. The study examines how high-density lipoproteins (HDL) interact with these immune cells, particularly a subset known as effector memory Tregs, to promote their longevity and function. By exploring the mechanisms involved, including the activation of certain signaling pathways, the research aims to uncover new insights that could lead to improved treatments for autoimmune and inflammatory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include adolescents and young adults with autoimmune conditions or those experiencing chronic inflammation.
Not a fit: Patients with acute infections or those not suffering from autoimmune or inflammatory diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing immune function and managing autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of HDL in immune regulation, suggesting that this approach may yield valuable insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Chougnet, Claire a. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Chougnet, Claire a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.