Investigating how a protein affects the intestinal barrier and immune response
Official title: TVP23B and Golgi Mediated Control of Intestinal Secretory Cells
Funded at Ut Southwestern Medical Center · NIH-11004092 · Data updated 2026-11-12
This study is looking at a protein called TVP23B to see how it helps keep our intestines healthy and protected from bad bacteria, and it's especially for people who might be dealing with intestinal diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $567,626 |
| NIH project number | 5R01DK133229-02 |
| Project ID | NIH-11004092 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting intestinal health or those at risk for intestinal infections.
✕Less likely to help
Patients with no gastrointestinal issues or those not at risk for intestinal diseases may not benefit from this research.
What this research studies
This research focuses on understanding the role of the TVP23B protein in maintaining the intestinal barrier, which is crucial for separating the body from harmful bacteria. By studying mice with a genetic mutation affecting this protein, researchers aim to uncover how deficiencies in TVP23B lead to increased susceptibility to intestinal diseases. The approach involves analyzing the function of specific intestinal cells and their ability to produce antimicrobial substances that protect against infections. This research could provide insights into new treatments for conditions related to intestinal health.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from intestinal diseases and infections.
How similar studies have gone: Other research has shown promising results in understanding the role of intestinal barrier proteins, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Turer, Emre Erol — Ut Southwestern Medical Center
- Study coordinator: Turer, Emre Erol
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.