Investigating how a protein affects the growth of certain viruses.
Cellular Mechanism of Oxysterol-Binding Protein (OSBP) in Viral Proliferation: A Chemical Biology Approach
This study is looking at how a protein called OSBP helps certain viruses, like coronaviruses, to multiply, and it’s testing new treatments that could block this protein to stop the viruses from spreading, which could lead to better options for patients dealing with viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11059102 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the oxysterol-binding protein (OSBP) in the replication of various single-stranded RNA viruses, including coronaviruses. By targeting OSBP with specific compounds, the study aims to develop new antiviral therapies that could inhibit viral proliferation. The approach involves using low doses of OSBP-targeting compounds to induce long-term repression of OSBP in cells, which has shown promising results in preventing viral replication. Patients may benefit from potential new treatments that could be effective against multiple viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by viral infections, particularly those caused by single-stranded RNA viruses like COVID-19.
Not a fit: Patients with viral infections caused by double-stranded RNA viruses or other non-viral conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral therapies that are effective against a wide range of RNA viruses.
How similar studies have performed: Previous research has shown success in targeting host proteins for antiviral development, indicating a promising avenue for this approach.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Burgett, Anthony Wg — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Burgett, Anthony Wg
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.