Investigating how a protein affects sodium reabsorption and high blood pressure
Novel Role Of ACTN4 in Sodium Reabsorption and Salt-Sensitive Hypertension
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-11000324
This study is looking at how a protein called ACTN4 affects the way your kidneys handle salt and blood pressure, especially for people who are sensitive to salt, to help find new ways to treat high blood pressure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11000324 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a protein called ACTN4 in sodium reabsorption and its connection to salt-sensitive hypertension. Using advanced organ-on-chip technology, researchers will study how mutations in ACTN4 influence sodium handling in kidney cells. The study aims to determine how these mutations affect blood pressure regulation by altering the activity of sodium transporters in the kidneys. By examining these mechanisms, the research seeks to provide insights into potential new treatments for hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with salt-sensitive hypertension or those at risk for developing high blood pressure.
Not a fit: Patients with hypertension not related to sodium reabsorption or those with other underlying causes of high blood pressure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing salt-sensitive hypertension in patients.
How similar studies have performed: Previous research has shown promising results in understanding sodium transport mechanisms, but this specific approach using ACTN4 is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FENG, DI — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: FENG, DI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.