Investigating how a protein affects sepsis and lung injury
Neutrophils in Sepsis: Role of CIRP
This study is looking at how a protein called CIRP makes sepsis worse and can lead to lung problems, and it aims to find new ways to help people with sepsis and lung injury by understanding how this protein affects certain immune cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project ID | NIH-10429996 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of cold-inducible RNA-binding protein (CIRP) in worsening sepsis and causing acute lung injury (ALI). The study examines how CIRP is released into the bloodstream during sepsis and leads to the expansion of a specific type of neutrophil that contributes to lung damage. By exploring the mechanisms involved, including the production of neutrophil extracellular traps (NETs), the research aims to identify potential therapeutic targets to mitigate the effects of sepsis and ALI. The approach includes both laboratory experiments and animal models to validate findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis or at risk of developing acute lung injury.
Not a fit: Patients with conditions unrelated to sepsis or acute lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for sepsis and acute lung injury, conditions that currently have no FDA-approved therapies.
How similar studies have performed: Previous research has shown promising results in understanding the role of neutrophils in sepsis, but the specific focus on CIRP and its mechanisms is relatively novel.
Where this research is happening
Manhasset, United States
- Feinstein Institute for Medical Research — Manhasset, United States (Active)
Researchers
- Principal investigator: Aziz, Monowar — Feinstein Institute for Medical Research
- Study coordinator: Aziz, Monowar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.