Investigating how a protein affects R-loop metabolism and neurodegeneration.
The functions of the zinc finger protein ZPR1 in R-loop metabolism and neurodegeneration.
This study is looking at a protein called ZPR1 to see how it helps manage R-loops, which can cause DNA damage and are connected to diseases like ALS and SMA, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10762448 on NIH RePORTER |
What this research studies
This research focuses on the zinc finger protein ZPR1 and its role in managing R-loops, which are structures formed during the transcription of DNA into RNA. Accumulation of R-loops can lead to DNA damage and is linked to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). The study aims to understand how ZPR1 interacts with other proteins involved in R-loop resolution and how its deficiency can lead to neurodegeneration. By exploring these mechanisms, the research seeks to uncover potential therapeutic targets for these debilitating conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with neurodegenerative diseases such as ALS or SMA.
Not a fit: Patients with neurodegenerative diseases not associated with R-loop metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases by targeting R-loop metabolism.
How similar studies have performed: Other research has shown promising results in targeting R-loop metabolism for neurodegenerative diseases, indicating that this approach may be viable.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Gangwani, Laxman Dass — University of Missouri-Columbia
- Study coordinator: Gangwani, Laxman Dass
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.