Investigating how a protein affects Parkinson's disease and Lewy Body Dementia
Official title: Molecular Mechanisms of Oxidation Resistance 1 in Parkinson's disease and Lewy Body Dementia
Funded at Medical University of South Carolina · NIH-11124888 · Data updated 2026-11-12
This study is looking at how a protein called Oxr1 might help protect brain cells from damage in people with Parkinson's disease and Lewy Body Dementia, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $568,064 |
| NIH project number | 5R01NS133688-03 |
| Project ID | NIH-11124888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease or Lewy Body Dementia.
✕Less likely to help
Patients with other neurodegenerative disorders unrelated to alpha-synuclein pathology may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called Oxidation Resistance 1 (Oxr1) in Parkinson's disease and Lewy Body Dementia. It aims to explore how Oxr1 can protect neurons from damage caused by the aggregation of alpha-synuclein, a protein linked to these conditions. By studying the mechanisms of Oxr1, researchers hope to uncover new insights into the neurodegenerative processes and identify potential therapeutic targets. The approach includes preclinical models to assess the neuroprotective effects of Oxr1 and its influence on cellular health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Parkinson's disease and Lewy Body Dementia.
How similar studies have gone: Previous research has shown promising results in understanding the role of proteins like Oxr1 in neuroprotection, indicating potential for success in this area.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Thomas, Bobby — Medical University of South Carolina
- Study coordinator: Thomas, Bobby
Related research
Other NIH-funded projects on the same topics.
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Dorsomedial Striatal Dopamine and Dementia in Parkinson’s Disease
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Gut microbes, brain inflammation, and dementia in Parkinson’s disease
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RNA editing and protein inclusions in dementia and Parkinson’s disease
A study in people with or at risk for dementia and Parkinson’s disease will explore how RNA editing and protein clumps in brain cells might drive disease processes and potentially point to new interventions.
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Molecular protections against oxidation in Parkinson’s disease and Lewy body dementia
A study to understand how Oxr1 helps neurons resist damage in Parkinson’s disease and Lewy body dementia, with potential to guide new treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.