Investigating how a protein affects kidney sodium regulation and blood pressure
The circadian clock protein BMAL and post-translational regulation of ENaC in the kidney
This study is looking at how a protein called BMAL1 helps control sodium levels in the kidneys, which can affect blood pressure, and it's doing this by testing special mice to see how these proteins work together.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10875278 on NIH RePORTER |
What this research studies
This research explores the role of the circadian clock protein BMAL1 in regulating sodium reabsorption in the kidneys through its interaction with the epithelial sodium channel (ENaC) and an adaptor protein called MARCKS. By using various genetically modified mouse models, the study aims to understand how these proteins function together and their impact on blood pressure regulation. The research will involve experiments to measure ENaC activity, sodium handling, and blood pressure in these mice, providing insights into the biological mechanisms at play.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with hypertension or kidney-related issues, particularly those who may benefit from improved sodium regulation.
Not a fit: Patients without hypertension or kidney problems are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing blood pressure and improving kidney function in patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of circadian rhythms in kidney function, suggesting that this approach may yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Alli, Abdel Ayube — University of Florida
- Study coordinator: Alli, Abdel Ayube
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.