Investigating how a protein affects kidney function and disease
Official title: Role of myosin 1e in podocyte biology and renal filtration
Funded at Upstate Medical University · NIH-10989960 · Data updated 2026-11-12
This study is looking at a protein called Myosin 1e that helps kidney cells do their job, and it's for anyone interested in how changes in this protein might lead to kidney problems, with the goal of finding new ways to keep kidneys healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $586,753 |
| NIH project number | 5R01DK083345-13 |
| Project ID | NIH-10989960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic kidney disease, particularly those with mutations in the MYO1E gene.
✕Less likely to help
Patients with acute kidney injury or those without any genetic mutations related to Myosin 1e may not benefit from this research.
What this research studies
This research focuses on the role of Myosin 1e, a protein crucial for the function of podocytes, which are cells in the kidneys that help filter blood. The project aims to understand how mutations in the gene for Myosin 1e can lead to chronic kidney disease by disrupting normal kidney function. Researchers will use various laboratory techniques to analyze how Myosin 1e operates and how its activation might protect kidney cells from damage. By studying these mechanisms, the research hopes to find new ways to preserve kidney function in patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help protect kidney function in patients with chronic kidney disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of cytoskeletal proteins in kidney function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Krendel, Mira — Upstate Medical University
- Study coordinator: Krendel, Mira
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.