Investigating how a protein affects inflammation in the intestines
GSDMD-dependent IL-1 signaling in intestinal inflammation
['FUNDING_P01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10861071
This study is looking at how a protein called Gasdermin D helps control inflammation in the gut, which could lead to new ways to treat or prevent inflammatory bowel disease (IBD) for patients like you.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10861071 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of Gasdermin D (GSDMD) in the release of a key inflammatory cytokine, IL-1β, which is involved in inflammatory bowel disease (IBD). The study explores how GSDMD interacts with other proteins in intestinal epithelial cells to regulate inflammation. By examining the mechanisms of GSDMD and its associated proteins, the research aims to uncover new insights into the causes of IBD and potential therapeutic targets. Patients may benefit from findings that could lead to new treatments for managing or preventing IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory bowel disease, including conditions like Crohn's disease and ulcerative colitis.
Not a fit: Patients with non-inflammatory bowel conditions or those not experiencing gastrointestinal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating inflammatory bowel disease.
How similar studies have performed: Other research has shown promising results in targeting inflammatory pathways in IBD, suggesting that this approach could yield significant insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PIZARRO, THERESA TORRES — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: PIZARRO, THERESA TORRES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.