Investigating how a protein affects inflammation after a stroke
Role of RIPK2 in the neuroinflammatory response to ischemic stroke
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-11111341
This study is looking at how a protein called RIPK2 affects inflammation in the brain after a stroke, and it aims to see if blocking this protein can help reduce brain damage and improve recovery for people who have had a stroke.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11111341 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of RIPK2, a protein involved in inflammation, in the context of ischemic stroke. The study aims to explore how inhibiting RIPK2 can reduce neuroinflammation, which is known to contribute to brain damage and neurological impairment following a stroke. By using animal models, the researchers will assess the effects of RIPK2 inhibition on stroke damage and recovery outcomes. The ultimate goal is to find new therapeutic strategies that could help limit the harmful effects of inflammation after a stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have experienced an ischemic stroke.
Not a fit: Patients who have not had a stroke or those with hemorrhagic stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that minimize brain damage and improve recovery for stroke patients.
How similar studies have performed: Previous research has shown promising results in reducing inflammation and improving outcomes in stroke models by targeting similar pathways, suggesting potential for success in this approach.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CANDELARIO-JALIL, EDUARDO JESUS — UNIVERSITY OF FLORIDA
- Study coordinator: CANDELARIO-JALIL, EDUARDO JESUS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury