Investigating how a protein affects inflammation after a stroke
Official title: Role of RIPK2 in the neuroinflammatory response to ischemic stroke
Funded at University of Florida · NIH-11111341 · Data updated 2026-11-12
This study is looking at how a protein called RIPK2 affects inflammation in the brain after a stroke, and it aims to see if blocking this protein can help reduce brain damage and improve recovery for people who have had a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $408,885 |
| NIH project number | 5R01NS129136-03 |
| Project ID | NIH-11111341 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who have experienced an ischemic stroke.
✕Less likely to help
Patients who have not had a stroke or those with hemorrhagic stroke may not benefit from this research.
What this research studies
This research focuses on understanding the role of RIPK2, a protein involved in inflammation, in the context of ischemic stroke. The study aims to explore how inhibiting RIPK2 can reduce neuroinflammation, which is known to contribute to brain damage and neurological impairment following a stroke. By using animal models, the researchers will assess the effects of RIPK2 inhibition on stroke damage and recovery outcomes. The ultimate goal is to find new therapeutic strategies that could help limit the harmful effects of inflammation after a stroke.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that minimize brain damage and improve recovery for stroke patients.
How similar studies have gone: Previous research has shown promising results in reducing inflammation and improving outcomes in stroke models by targeting similar pathways, suggesting potential for success in this approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Candelario-Jalil, Eduardo Jesus — University of Florida
- Study coordinator: Candelario-Jalil, Eduardo Jesus
Related research
Other NIH-funded projects on the same topics.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
-
Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
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Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.