Investigating how a protein affects inflammation
Official title: Mechanistic Investigation of the Role of FBXW7 in Inflammasome Activation
Funded at Scripps Research Institute, the · NIH-11119011 · Data updated 2026-11-12
This study is looking at how a protein called FBXW7 helps control inflammation in the body, which could be important for people dealing with chronic inflammatory diseases or neurodegenerative conditions, and it hopes to find new ways to treat these issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | June 17, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $230,000 |
| NIH project number | 5R21AI182967-02 |
| Project ID | NIH-11119011 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory diseases or neurodegenerative conditions.
✕Less likely to help
Patients with acute infections or those not experiencing chronic inflammation may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific protein, FBXW7, in the activation of the NLRP3 inflammasome, which is crucial for regulating inflammatory responses in the body. The study aims to uncover the mechanisms by which FBXW7 influences the assembly and activation of NLRP3, particularly in the context of chronic inflammatory diseases and neurodegenerative conditions. By examining how FBXW7 interacts with NLRP3, the research seeks to provide insights into potential therapeutic targets for managing inflammation-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic inflammatory diseases and neurodegenerative disorders.
How similar studies have gone: Previous research has shown promising results in understanding inflammasome activation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Reed, Steven I — Scripps Research Institute, the
- Study coordinator: Reed, Steven I
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.