Investigating how a protein affects heart metabolism during exercise and heart failure
The Role of GCN5L1 Mediated Mitochondria to Nucleus Retrograde Cardiac Metabolism Reprogramming in Exercise and Heart Failure
This study is looking at how a protein called GCN5L1 affects heart health and energy production, especially in people with heart failure and those who exercise, to find new ways to help improve heart function.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11072114 on NIH RePORTER |
What this research studies
This research explores the role of a specific protein, GCN5L1, in regulating heart metabolism, particularly in the context of heart failure and exercise. It aims to understand how this protein influences the heart's energy production and function by examining its effects on mitochondrial processes. The study involves analyzing heart tissues from patients and animal models to uncover the molecular mechanisms that may contribute to heart failure progression and the benefits of exercise. By identifying these pathways, the research seeks to provide insights into potential therapeutic targets for improving heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with heart failure or those experiencing impaired cardiac function.
Not a fit: Patients with stable heart conditions not related to heart failure may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart function and metabolism in patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function and its role in heart health, indicating that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Zhang, Manling — University of Pittsburgh at Pittsburgh
- Study coordinator: Zhang, Manling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.