Investigating how a protein affects heart function in pulmonary hypertension
Role of HADHA in regulating right ventricular mitochondrial structure and energetic function in pulmonary hypertension
This study is looking at how a protein called HADHA affects the right side of the heart in people with pulmonary hypertension, hoping to find new ways to help improve heart function for those dealing with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Providence VA Medical Center NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10925838 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the HADHA protein in the right ventricle of the heart, particularly in patients with pulmonary hypertension (PH). It aims to explore how changes in mitochondrial function and structure, influenced by HADHA, can lead to heart dysfunction. By examining the relationship between HADHA, cardiolipin, and mitochondrial energy production, the research seeks to uncover new therapeutic strategies to improve heart function in PH. Patients may benefit from insights that could lead to targeted treatments for RV dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension who are experiencing right ventricular dysfunction.
Not a fit: Patients without pulmonary hypertension or those with isolated left ventricular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function in patients with pulmonary hypertension.
How similar studies have performed: While the specific approach of targeting HADHA in pulmonary hypertension is novel, similar research has shown promise in understanding mitochondrial function in heart diseases.
Where this research is happening
Providence, United States
- Providence VA Medical Center — Providence, United States (Active)
Researchers
- Principal investigator: Choudhary, Gaurav — Providence VA Medical Center
- Study coordinator: Choudhary, Gaurav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.