Investigating how a protein affects heart function in pulmonary hypertension
Official title: Role of HADHA in regulating right ventricular mitochondrial structure and energetic function in pulmonary hypertension
Funded at Providence VA Medical Center · NIH-10925838 · Data updated 2026-11-12
This study is looking at how a protein called HADHA affects the right side of the heart in people with pulmonary hypertension, hoping to find new ways to help improve heart function for those dealing with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Providence VA Medical Center NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006287-01A1 |
| Project ID | NIH-10925838 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary hypertension who are experiencing right ventricular dysfunction.
✕Less likely to help
Patients without pulmonary hypertension or those with isolated left ventricular dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the role of the HADHA protein in the right ventricle of the heart, particularly in patients with pulmonary hypertension (PH). It aims to explore how changes in mitochondrial function and structure, influenced by HADHA, can lead to heart dysfunction. By examining the relationship between HADHA, cardiolipin, and mitochondrial energy production, the research seeks to uncover new therapeutic strategies to improve heart function in PH. Patients may benefit from insights that could lead to targeted treatments for RV dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function in patients with pulmonary hypertension.
How similar studies have gone: While the specific approach of targeting HADHA in pulmonary hypertension is novel, similar research has shown promise in understanding mitochondrial function in heart diseases.
Where this research is happening
-
Providence VA Medical Center
Providence, United States Active
Researchers
- Principal investigator: Choudhary, Gaurav — Providence VA Medical Center
- Study coordinator: Choudhary, Gaurav
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.