Investigating how a protein affects heart function and failure
Role of mRNA-binding protein tristetraprolin in cardiac mRNA regulation and the development of heart failure
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11001510
This study is looking at a protein called TTP to see how it affects heart health and the way the heart uses fats and proteins, which could help us find new ways to treat heart failure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11001510 on ClinicalTrials.gov |
What this research studies
This research explores the role of tristetraprolin (TTP), a protein that regulates mRNA, in heart metabolism and the development of heart failure. By studying mice that lack TTP, researchers aim to understand how this protein influences the degradation of specific mRNAs related to fatty acid and branched-chain amino acid metabolism. The study will involve assessing the impact of TTP on cardiac function and metabolism, potentially revealing new insights into heart failure mechanisms. Patients may benefit from findings that could lead to novel therapeutic strategies for heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart failure or those at risk of developing heart failure due to metabolic issues.
Not a fit: Patients with heart failure caused by non-metabolic factors may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and outcomes for patients with heart failure.
How similar studies have performed: Previous research has shown that targeting mRNA regulation can lead to significant advancements in understanding and treating metabolic diseases, suggesting potential success for this approach.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARDEHALI, HOSSEIN — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: ARDEHALI, HOSSEIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.