Investigating how a protein affects heart damage from alcohol
Official title: TRAF3IP2 as a Proinflammatory Mediator of Alcohol-related Cardiomyopathy
Funded at Lsu Health Sciences Center · NIH-10996520 · Data updated 2026-11-12
This study is looking at how a protein called TRAF3IP2 might play a part in heart damage from drinking too much alcohol, and it aims to find out if stopping this protein can help protect the heart, which could lead to better treatments for people with heart problems caused by alcohol.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $40,827 |
| NIH project number | 1F30AA031632-01A1 |
| Project ID | NIH-10996520 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of heavy alcohol consumption who may be experiencing heart-related issues.
✕Less likely to help
Patients who do not consume alcohol or have no cardiovascular issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of TRAF3IP2, a protein that may contribute to heart damage caused by excessive alcohol consumption, known as Alcohol-related Cardiomyopathy. The study will explore how alcohol exposure activates cardiac fibroblasts, leading to inflammation and heart dysfunction. Researchers will use both laboratory experiments and animal models to determine if blocking TRAF3IP2 can prevent these harmful effects. Patients may benefit from insights that could lead to new treatments for heart issues related to alcohol use.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing heart damage in individuals who consume excessive alcohol.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of alcohol-related heart damage, but the specific role of TRAF3IP2 is still being explored.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Harris, Nicholas R — Lsu Health Sciences Center
- Study coordinator: Harris, Nicholas R
Related research
Other NIH-funded projects on the same topics.
-
Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
-
Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
-
Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
-
Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
-
Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
-
Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.