Investigating how a protein affects heart cell growth and healing
Official title: Function and Mechanism of the Intercalated Disc Protein XinB in Cardiomyocyte Proliferation and Cardiac Regeneration
Funded at University of South Florida · NIH-11074650 · Data updated 2026-11-12
This study is looking at a protein called XinB in heart cells to see how it helps the heart grow and heal, especially as we get older, with the goal of finding ways to improve heart health for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $507,647 |
| NIH project number | 5R01HL168900-03 |
| Project ID | NIH-11074650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults, particularly those over 21 years old, who may be experiencing heart-related issues or are at risk due to age.
✕Less likely to help
Patients with non-cardiac conditions or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific protein, XinB, found in heart muscle cells, which is crucial for their growth and the heart's ability to heal after injury. The study aims to uncover how this protein interacts with other components in heart cells to maintain their structure and function, especially as people age. By exploring these molecular mechanisms, the research hopes to provide insights into improving heart health and addressing cardiovascular diseases, which are particularly prevalent in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart regeneration and improve outcomes for patients with cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of proteins in heart function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Wang, Da-Zhi — University of South Florida
- Study coordinator: Wang, Da-Zhi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.