Investigating how a protein affects gene expression in the auditory brainstem related to Fragile X Syndrome.
Role of Fragile X Mental Retardation Protein on Gene Expression in Auditory Brainstem Development
This study is looking at how a missing protein affects hearing in mice with Fragile X Syndrome, which could help us understand why people with this condition sometimes have trouble processing sounds.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11052644 on NIH RePORTER |
What this research studies
This research focuses on Fragile X Syndrome (FXS), the most common inherited autism spectrum disorder, particularly its impact on auditory processing. The study will utilize a mouse model lacking the Fragile X mental retardation protein (FMRP) to explore how this protein influences gene expression in the auditory brainstem. By examining the stability of specific mRNAs and their protein levels, the research aims to uncover the mechanisms behind auditory hypersensitivity often seen in individuals with FXS. The findings could provide insights into the biological underpinnings of auditory processing issues in FXS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fragile X Syndrome or those exhibiting symptoms related to auditory processing issues.
Not a fit: Patients without Fragile X Syndrome or those not experiencing auditory hypersensitivity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for auditory hypersensitivity in patients with Fragile X Syndrome.
How similar studies have performed: While the role of FMRP in other contexts has been studied, this specific investigation into its effects on the auditory brainstem is relatively novel.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Sakano, Hitomi — Ut Southwestern Medical Center
- Study coordinator: Sakano, Hitomi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.