Investigating how a protein affects diabetes and liver disease
Hepatic TGFbeta1 in Control of Type 2 Diabetes and NASH via FoxO1 Signaling
This study is looking at how a protein called TGFβ1 affects blood sugar and liver health in people with type 2 diabetes and a liver condition called NASH, hoping to find new ways to help treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project ID | NIH-10979154 on NIH RePORTER |
What this research studies
This research explores the role of a protein called TGFβ1 in the development of type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH), a liver condition. It focuses on understanding how TGFβ1 influences glucose metabolism and liver function through a signaling pathway involving a protein called FoxO1. By examining the effects of TGFβ1 on liver cells, the research aims to uncover mechanisms that lead to insulin resistance and liver inflammation. Patients may benefit from insights that could lead to new treatments for T2D and NASH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes or non-alcoholic steatohepatitis.
Not a fit: Patients without type 2 diabetes or liver conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing type 2 diabetes and liver disease.
How similar studies have performed: Previous research has shown that targeting similar signaling pathways can lead to significant advancements in understanding and treating metabolic diseases.
Where this research is happening
College Station, UNITED STATES
- Texas A&m Agrilife Research — College Station, United States (Active)
Researchers
- Principal investigator: Guo, Shaodong — Texas A&m Agrilife Research
- Study coordinator: Guo, Shaodong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.