Investigating how a protein affects dental pulp stem cells for tissue regeneration
The Role of DPP in Dental Pulp Stem Cells and its Potential in Tissue Regeneration
['FUNDING_R01'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10596123
This study is looking at a special protein called dentin phosphophoryn to see how it helps dental pulp stem cells heal and grow, which could lead to better treatments for common dental problems like deep cavities and exposed nerves.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10596123 on ClinicalTrials.gov |
What this research studies
This research explores the role of dentin phosphophoryn (DPP) in dental pulp stem cells (DPSCs) and its potential to aid in tissue regeneration. By examining how DPP activates the Wnt signaling pathway, the study aims to understand how it influences the differentiation and migration of DPSCs. This could lead to new treatments for dental issues like deep caries and pulp exposures, which are common problems in dental health. The research employs advanced biological assays and signaling pathway analysis to uncover these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from deep dental caries or pulp exposure who may benefit from regenerative dental treatments.
Not a fit: Patients with non-dental related health issues or those who do not have dental pulp problems may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance the regeneration of dental tissues, improving outcomes for patients with dental pulp issues.
How similar studies have performed: Previous research has shown promising results in using stem cells for tissue regeneration, indicating that this approach may lead to significant advancements in dental treatments.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GEORGE, ANNE — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: GEORGE, ANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.