Investigating how a protein affects chronic bacterial infections
HMGB1-mediated host response to chronic bacterial infection
This study is looking at a protein called HMGB1 that might help break down stubborn bacterial clusters in chronic infections, with the goal of finding better treatments to help people who are dealing with these long-lasting infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-10899468 on NIH RePORTER |
What this research studies
This research focuses on the role of High Mobility Group Box 1 (HMGB1), a protein that influences how the body responds to chronic bacterial infections. It examines how HMGB1 can destabilize biofilms formed by bacteria, making them more susceptible to treatment. The study utilizes various methodologies to explore the interactions between HMGB1 and bacterial structures, aiming to uncover new therapeutic strategies for managing persistent infections. By understanding these mechanisms, the research seeks to improve patient outcomes in those suffering from chronic infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic bacterial infections, particularly those caused by biofilm-forming bacteria.
Not a fit: Patients with acute bacterial infections or those not affected by biofilm-related chronic infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively combat chronic bacterial infections.
How similar studies have performed: Previous research has shown promise in targeting biofilms and chronic infections, suggesting that this approach could yield significant advancements.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Goodman, Steven D — Research Inst Nationwide Children's Hosp
- Study coordinator: Goodman, Steven D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.