Investigating how a protein affects cell growth and DNA repair in pulmonary arterial hypertension.
ZFP36, an RNA Binding Protein that Regulates DNA Repair and Cell Proliferation in PAH
This study is looking at how a protein called ZFP36 affects lung cells in young people with pulmonary arterial hypertension (PAH), with the hope of finding new ways to help improve their health and quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11140348 on NIH RePORTER |
What this research studies
This research focuses on pulmonary arterial hypertension (PAH), a serious condition that leads to high blood pressure in the lungs and significantly impacts the quality of life for young patients. The study aims to understand the role of ZFP36, an RNA-binding protein, in regulating gene expression related to cell proliferation and apoptosis in pulmonary arterial smooth muscle cells. By analyzing lung tissue from PAH patients and conducting laboratory experiments, researchers will explore how ZFP36 influences DNA repair mechanisms and cell survival, potentially leading to new therapeutic strategies for PAH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension, particularly younger patients experiencing significant symptoms.
Not a fit: Patients with other forms of pulmonary hypertension or those without a diagnosis of pulmonary arterial hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve outcomes and quality of life for patients with pulmonary arterial hypertension.
How similar studies have performed: While the specific role of ZFP36 in PAH is relatively novel, previous research has shown that targeting RNA-binding proteins can lead to significant advancements in understanding and treating various diseases.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Eghbali, Mansoureh — University of California Los Angeles
- Study coordinator: Eghbali, Mansoureh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.