Investigating how a protein affects brain recovery after childhood concussions
Caveolin-1 contributes to the long-term function and structure of the neurovascular unit after juvenile concussion
This study is looking at how mild brain injuries in kids can affect their thinking skills as they grow up, and it’s exploring a special protein that might help the brain heal better after these injuries, with the goal of finding new ways to support brain health for young people who have had concussions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11225782 on NIH RePORTER |
What this research studies
This research focuses on understanding the long-term effects of mild traumatic brain injuries (mTBI) in children, particularly how these injuries can lead to cognitive decline and dementia as they age. The study will explore the role of a specific protein, Caveolin-1, in the brain's recovery process after such injuries. By examining cellular and molecular changes in the neurovascular unit, researchers aim to develop new therapeutic strategies to improve brain health following juvenile concussions. The approach includes using advanced imaging techniques and targeted treatments to assess the impact of Caveolin-1 on brain function over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 who have suffered a mild traumatic brain injury.
Not a fit: Patients who have not experienced a concussion or those over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and prevent cognitive decline in children who have experienced concussions.
How similar studies have performed: Previous research has shown promising results in targeting Caveolin-1 for recovery after strokes, suggesting potential for success in similar approaches for juvenile concussions.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Obenaus, Andre — University of California Riverside
- Study coordinator: Obenaus, Andre
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.