Investigating how a protein affects brain immune cells in Alzheimer's disease
Functional dissection of fibronectin type 3 domains of SORL1 in Alzheimers disease associated microglia
This study is looking at how a protein called SORL1 affects brain immune cells, which could help us find new ways to improve their function and slow down Alzheimer's disease, potentially leading to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11042191 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein, SORL1, in the functioning of microglia, which are immune cells in the brain, particularly in the context of Alzheimer's disease. The study aims to explore how SORL1 influences microglial activities such as their ability to clear debris and respond to inflammation. By examining the molecular mechanisms involved, the research seeks to identify potential therapeutic targets that could improve microglial function and, consequently, the progression of Alzheimer's disease. Patients may benefit from insights gained that could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk for developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that enhance the function of brain immune cells, potentially slowing the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting microglial functions in Alzheimer's disease, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Sher, Falak — Columbia University Health Sciences
- Study coordinator: Sher, Falak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.