Investigating how a protein affects brain function in Alzheimer's disease
Role of VAMP1 in synaptic transmission and Alzheimer's dementia
['FUNDING_R01'] · AUGUSTA UNIVERSITY · NIH-10773029
This study is looking at a protein called VAMP1 to see how it affects memory and thinking, especially in relation to a harmful substance linked to Alzheimer's disease, with the hope of finding new ways to help people with dementia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-10773029 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a specific protein, VAMP1, in the brain's synaptic transmission processes, which are crucial for memory and cognition. By examining how VAMP1 influences the production of beta-amyloid, a toxic component associated with Alzheimer's disease, the researchers aim to uncover new therapeutic targets. The study involves genetic screening to identify variations in the VAMP1 gene that may be linked to late-onset Alzheimer's. Through this approach, the research seeks to provide insights that could lead to better treatments for patients suffering from dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals, particularly those with a genetic predisposition to late-onset Alzheimer's disease.
Not a fit: Patients with early-onset Alzheimer's or those without genetic risk factors for the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting synaptic proteins for Alzheimer's treatment, indicating potential for success in this innovative approach.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEAK, FERENC — AUGUSTA UNIVERSITY
- Study coordinator: DEAK, FERENC
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.