Investigating how a protein affects brain cell interactions in Alzheimer's and related diseases
ApoE, lipid and immune mechanisms of human neurons and glia
This study is looking at how a protein called APOE affects brain cells and their support cells when there are issues with fats and inflammation, which can happen in diseases like Alzheimer's and Parkinson's, to help find new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project ID | NIH-10590145 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of apolipoprotein E (APOE) in the interactions between neurons and glial cells, particularly in the context of lipid imbalances and inflammation associated with neurodegenerative diseases like Alzheimer's, Parkinson's, and Lewy body dementia. By utilizing advanced human stem cell models, the study aims to uncover how APOE influences cellular responses to these stressors, which could lead to better insights into the mechanisms of brain degeneration. The research will explore how disruptions in lipid transport and inflammatory responses contribute to the progression of these diseases, potentially identifying new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease, Parkinson's disease, or Lewy body dementia.
Not a fit: Patients with neurodegenerative diseases unrelated to lipid metabolism or inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease and other neurodegenerative conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of APOE in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Belmont, United States
- Mclean Hospital — Belmont, United States (Active)
Researchers
- Principal investigator: Isacson, Ole — Mclean Hospital
- Study coordinator: Isacson, Ole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.