Investigating how a protein affects blood vessel health in heart disease
The role of shear induced endothelial ZBTB46 in atherosclerosis
This study is looking at a protein called ZBTB46 to see how it affects the development of atherosclerosis, a condition that can cause heart problems, and it aims to find new ways to help treat heart disease by understanding how changes in blood flow influence this protein in the cells that line our blood vessels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10864033 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called ZBTB46 in the development of atherosclerosis, a condition that can lead to serious heart problems. The study examines how changes in blood flow affect the expression of ZBTB46 in endothelial cells, which line blood vessels. By exploring how ZBTB46 influences cell behavior, including inflammation and cell death, the researchers aim to uncover mechanisms that contribute to atherosclerosis. Patients may benefit from insights that could lead to new treatments for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis, including those with cardiovascular disease or related risk factors.
Not a fit: Patients with conditions unrelated to atherosclerosis or those who do not have cardiovascular risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating atherosclerosis and related cardiovascular diseases.
How similar studies have performed: Previous research has shown that targeting specific proteins involved in endothelial cell function can lead to significant advancements in understanding and treating cardiovascular diseases.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Rezvan, Amir — Emory University
- Study coordinator: Rezvan, Amir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.