Investigating how a protein affects blood vessel health in diabetes
Official title: Dual Role of HSP70 in Diabetes-Induced Vascular Dysfunction
Funded at Florida Institute of Technology · NIH-10515009 · Data updated 2026-11-12
This study is looking at how a protein called HSP70 affects blood vessel health when blood sugar levels are high, which is important for people with diabetes, and it hopes to find new ways to help keep their blood vessels working well.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Institute of Technology NIH-funded |
| Lab location | 1 site (Melbourne, United States) |
| Project start | August 4, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $434,178 |
| NIH project number | 1R15DK131511-01A1 |
| Project ID | NIH-10515009 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with diabetes who are experiencing vascular complications.
✕Less likely to help
Patients without diabetes or those with vascular issues unrelated to diabetes may not benefit from this research.
What this research studies
This research explores the role of Heat-shock protein 70 (HSP70) in the vascular damage caused by high blood sugar levels in diabetes. It aims to understand how different forms of HSP70 interact with calcium signaling in blood vessels, which is crucial for their proper function. By examining the effects of HSP70 under hyperglycemic conditions, the study seeks to uncover mechanisms that lead to vascular dysfunction. This could provide insights into potential therapeutic targets for improving vascular health in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect blood vessels from damage in diabetic patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of HSP70 in other conditions, suggesting potential for success in this novel application.
Where this research is happening
-
Florida Institute of Technology
Melbourne, United States Active
Researchers
- Principal investigator: Nunes, Kenia Pedrosa — Florida Institute of Technology
- Study coordinator: Nunes, Kenia Pedrosa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.