Investigating how a protein affects blood vessel healing after angioplasty
Official title: The Matricellular Protein Cyr61 Signaling Axis in Arterial Restenosis
Funded at University of Texas of the Permian Basin · NIH-10647849 · Data updated 2026-11-12
This study is looking at how a protein called Cyr61 helps blood vessel cells move and heal after procedures like angioplasty, with the goal of finding new ways to improve treatments for patients who experience complications afterward.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas of the Permian Basin NIH-funded |
| Lab location | 1 site (Odessa, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $484,198 |
| NIH project number | 5R01HL153529-04 |
| Project ID | NIH-10647849 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have undergone angioplasty or stenting and are at risk for arterial restenosis.
✕Less likely to help
Patients who have not had any vascular interventions or those with non-cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of the Cyr61 protein in the migration of vascular smooth muscle cells, which is crucial for healing arteries after procedures like angioplasty and stenting. The study aims to uncover new therapeutic strategies by exploring how Cyr61 interacts with other proteins to influence cell movement and healing in blood vessels. By using advanced techniques to isolate specific cell components, researchers hope to identify novel signaling pathways that could lead to better treatments for arterial restenosis, a common complication after vascular interventions.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that reduce the risk of arterial restenosis, improving outcomes for patients undergoing angioplasty.
How similar studies have gone: Other research has shown promising results in targeting similar signaling pathways for improving vascular healing, indicating that this approach has potential for success.
Where this research is happening
-
University of Texas of the Permian Basin
Odessa, United States Active
Researchers
- Principal investigator: Cui, Mei-Zhen — University of Texas of the Permian Basin
- Study coordinator: Cui, Mei-Zhen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.